Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection
Monoallelic or biallelic RAD51C germline mutations results in chromosome instability disorders such as fanconi anemia (FA) and cancers. The bona fide function of RAD51C is to assist RAD51 nucleoprotein filament onto single strand DNA to complete Homologous Recombination (HR) repair. In addition to H...
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| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/164979 |
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| Institution: | Nanyang Technological University |
| Language: | English |