Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling

Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling

HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA. Recently, a new function of HMGA2 as a replication fork chaperone that protects stem and cancer cells from replication fork collapse ind...

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Bibliographic Details
Main Authors: Zhao, Xiaodan, Peter, Sabrina, Dröge, Peter, Yan, Jie
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
DNA Supercoiling
Replication Fork
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/88125
http://hdl.handle.net/10220/45636
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/88125
http://hdl.handle.net/10220/45636

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