Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling

• Main Authors: Zhao, Xiaodan, Peter, Sabrina, Dröge, Peter, Yan, Jie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DNA Supercoiling; Replication Fork; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88125; http://hdl.handle.net/10220/45636
• Institution: Nanyang Technological University

HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA. Recently, a new function of HMGA2 as a replication fork chaperone that protects stem and cancer cells from replication fork collapse ind...