Gsαᴿ²⁰¹ᶜ and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

• Main Authors: Palmisano, Biagio, Labella, Rossella, Donsante, Samantha, Remoli, Cristina, Spica, Emanuela, Coletta, Ilenia, Farinacci, Giorgia, Venti, Michele Dello Spedale, Saggio, Isabella, Serafini, Marta, Robey, Pamela Gehron, Corsi, Alessandro, Riminucci, Mara
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Adiponectin; Bone Marrow Cell
• Online Access: https://hdl.handle.net/10356/165114
• Institution: Nanyang Technological University

The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal skeleton. Hence, the dysregulated activity of Gsα due to gain-of-function mutations (R201C/R201H) results in severe architectural and functional derangements of the...