Adipose-specific PPARα knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue

• Main Authors: Hinds, Terry D., Kipp, Zachary A., Xu, Mei, Yiannikouris, Frederique B., Morris, Andrew J., Stec, Donald F., Wahli, Walter, Stec, David E.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Obesity; Cholesterol Esters
• Online Access: https://hdl.handle.net/10356/165261
• Institution: Nanyang Technological University

The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (PparaFatKO) mice to...