Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy

Responsive nanosystems for tumor treatment with high specificity and sensitivity have aroused great attention. Herein, we develop a tumor microenvironment responsive and near-infrared (NIR)-activatable theranostic nanoreactor for imaging-guided anticancer therapy. The nanoreactor (SnO2–x@AGP) is com...

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Main Authors: Feng, Lili, Zhao, Ruoxi, Yang, Lu, Liu, Bin, Dong, Shuming, Qian, Cheng, Liu, Jiawei, Zhao, Yanli
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/165515
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1655152023-06-21T08:32:30Z Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy Feng, Lili Zhao, Ruoxi Yang, Lu Liu, Bin Dong, Shuming Qian, Cheng Liu, Jiawei Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Science::Chemistry Cancer Phototherapy Multimodal Imaging Responsive nanosystems for tumor treatment with high specificity and sensitivity have aroused great attention. Herein, we develop a tumor microenvironment responsive and near-infrared (NIR)-activatable theranostic nanoreactor for imaging-guided anticancer therapy. The nanoreactor (SnO2–x@AGP) is comprised of poly(vinylpyrrolidine) encapsulated hollow mesoporous black SnO2–x nanoparticles coloaded with glucose oxidase (GOx) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). The constructed nanoreactor can be specifically activated through endogenous H2O2 by an NIR-mediated “bursting-like” process to enhance its imaging and therapeutic functions. Black SnO2–x with abundant oxygen vacancies expedites effective separation of electron–hole pairs from energy-band structure and endows them with strong hyperthermia effect upon NIR laser irradiation. The generating toxic H2O2 with the assistance of GOx provides SnO2–x@AGP with the capacity of oxidative stress therapy. Ascended H2O2 can activate ABTS into ABTS•+. ABTS•+ not only possesses significant NIR absorption properties, but also disrupts intracellular glutathione to generate excessive reactive oxygen species for improved phototherapy, leading to more effective treatment together with oxidative stress therapy. Thus, SnO2–x@AGP with NIR-mediated and H2O2-activated performance presents tumor inhibition efficacy with minimized damage to normal tissues. These outstanding characteristics of SnO2–x@AGP bring an insight into the development of activatable nanoreactors for smart, precise, and non-invasive cancer theranostics. Agency for Science, Technology and Research (A*STAR) National Research Foundation (NRF) Submitted/Accepted version This research is financially supported by the National Natural Science Foundation of China (NSFC 52002091), the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG grant (A20E5c0081), the Singapore National Research Foundation Investigatorship (NRFNRFI2018-03), and the Fundamental Research Funds for the Central Universities. 2023-03-29T01:29:20Z 2023-03-29T01:29:20Z 2023 Journal Article Feng, L., Zhao, R., Yang, L., Liu, B., Dong, S., Qian, C., Liu, J. & Zhao, Y. (2023). Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy. ACS Nano, 17(2), 1622-1637. https://dx.doi.org/10.1021/acsnano.2c11470 1936-0851 https://hdl.handle.net/10356/165515 10.1021/acsnano.2c11470 2 17 1622 1637 en A20E5c0081 NRFNRFI2018-03 ACS Nano This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © 2023 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.2c11470. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Cancer Phototherapy
Multimodal Imaging
spellingShingle Science::Chemistry
Cancer Phototherapy
Multimodal Imaging
Feng, Lili
Zhao, Ruoxi
Yang, Lu
Liu, Bin
Dong, Shuming
Qian, Cheng
Liu, Jiawei
Zhao, Yanli
Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
description Responsive nanosystems for tumor treatment with high specificity and sensitivity have aroused great attention. Herein, we develop a tumor microenvironment responsive and near-infrared (NIR)-activatable theranostic nanoreactor for imaging-guided anticancer therapy. The nanoreactor (SnO2–x@AGP) is comprised of poly(vinylpyrrolidine) encapsulated hollow mesoporous black SnO2–x nanoparticles coloaded with glucose oxidase (GOx) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). The constructed nanoreactor can be specifically activated through endogenous H2O2 by an NIR-mediated “bursting-like” process to enhance its imaging and therapeutic functions. Black SnO2–x with abundant oxygen vacancies expedites effective separation of electron–hole pairs from energy-band structure and endows them with strong hyperthermia effect upon NIR laser irradiation. The generating toxic H2O2 with the assistance of GOx provides SnO2–x@AGP with the capacity of oxidative stress therapy. Ascended H2O2 can activate ABTS into ABTS•+. ABTS•+ not only possesses significant NIR absorption properties, but also disrupts intracellular glutathione to generate excessive reactive oxygen species for improved phototherapy, leading to more effective treatment together with oxidative stress therapy. Thus, SnO2–x@AGP with NIR-mediated and H2O2-activated performance presents tumor inhibition efficacy with minimized damage to normal tissues. These outstanding characteristics of SnO2–x@AGP bring an insight into the development of activatable nanoreactors for smart, precise, and non-invasive cancer theranostics.
author2 School of Chemistry, Chemical Engineering and Biotechnology
author_facet School of Chemistry, Chemical Engineering and Biotechnology
Feng, Lili
Zhao, Ruoxi
Yang, Lu
Liu, Bin
Dong, Shuming
Qian, Cheng
Liu, Jiawei
Zhao, Yanli
format Article
author Feng, Lili
Zhao, Ruoxi
Yang, Lu
Liu, Bin
Dong, Shuming
Qian, Cheng
Liu, Jiawei
Zhao, Yanli
author_sort Feng, Lili
title Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
title_short Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
title_full Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
title_fullStr Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
title_full_unstemmed Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
title_sort tumor-specific nir-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
publishDate 2023
url https://hdl.handle.net/10356/165515
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