Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy

• Main Authors: Lee, Shi Hao, Yap, Yeannie H. Y., Lim, Chew Leng, Woo, Amanda Rui En, Lin, Valerie Chun Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Progesterone Receptor; Gene Expression Regulation
• Online Access: https://hdl.handle.net/10356/165526
• Institution: Nanyang Technological University

Progesterone receptor (PGR) is a member of the nuclear receptor superfamily of transcription factors. It is critical for mammary stem cells expansion, mammary ductal branching and alveologenesis. The transcriptional activity of PGR is mainly mediated by activation functions AF1 and AF2. Although the...