Catalytic enantioselective addition of diethylzinc to ketones using chiral biisoquinoline ligands.

• Main Author: Muhammad Firdaus Abdul Raub.
• Other Authors: Zaher Judeh
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis; DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: http://hdl.handle.net/10356/16597
• Institution: Nanyang Technological University

Biisoquinolines have been known to be good chelating agents. Four chiral biisoquinoline-based ligands were synthesized and used for asymmetric catalytic addition of diethylzinc to ketones. The reaction was tested for optimal conditions – type of ligands, catalyst loading, temperature, type of sol...