BMP-smad pathway in DNA damage response
DNA damage response is a mechanism that can prevents cancer development. In DNA damage response, ATM-p53 pathway is one of the pathways activated to induce DNA repair, cell cycle arrest and apoptosis which ultimately prevent tumorgenesis. Recent genetic studies have revealed that BMP-Smad pathway ha...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project |
| Language: | English |
| Published: |
2009
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/16673 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | DNA damage response is a mechanism that can prevents cancer development. In DNA damage response, ATM-p53 pathway is one of the pathways activated to induce DNA repair, cell cycle arrest and apoptosis which ultimately prevent tumorgenesis. Recent genetic studies have revealed that BMP-Smad pathway has a function that suppresses tumorgenesis. An inactivation of this pathway leads to tumorigenesis in both human and mouse. However, their interaction is still a mystery because BMP-Smad pathway is a complex pathway. Previous studies have shown that deficiency of p53 gene leads to activation of BMP-Smad pathway. Hence, in this project, DNA damage proteins (p53 and ATM) were used to test the effect of Smad1 whether there is a possible link between ATM-p53 and BMP-Smad pathway. The experiment findings have shown that elevation of Smad1 plays similar role as p53 in DNA damage response, cell transformation and tumorigenesis. Furthermore, Smad1 appears to up-regulate when p53 and ATM are deficient. Hence, a failure in ATM-p53 pathway activates the BMP-Smad1 pathway which may serve as a compensatory mechanism. This study and the results obtained establish that BMP-Smad1 signaling is an integral part of DNA damage response. |
|---|