BMP-smad pathway in DNA damage response

DNA damage response is a mechanism that can prevents cancer development. In DNA damage response, ATM-p53 pathway is one of the pathways activated to induce DNA repair, cell cycle arrest and apoptosis which ultimately prevent tumorgenesis. Recent genetic studies have revealed that BMP-Smad pathway ha...

Full description

Saved in:
Bibliographic Details
Main Author: Gan, Hwee Yee
Other Authors: Liao Kin
Format: Final Year Project
Language:English
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/10356/16673
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-16673
record_format dspace
spelling sg-ntu-dr.10356-166732023-03-03T15:34:35Z BMP-smad pathway in DNA damage response Gan, Hwee Yee Liao Kin School of Chemical and Biomedical Engineering A*STAR Institute of Molecular and Cell Biology Chau Fung Ling DRNTU::Engineering::Chemical engineering::Biotechnology DNA damage response is a mechanism that can prevents cancer development. In DNA damage response, ATM-p53 pathway is one of the pathways activated to induce DNA repair, cell cycle arrest and apoptosis which ultimately prevent tumorgenesis. Recent genetic studies have revealed that BMP-Smad pathway has a function that suppresses tumorgenesis. An inactivation of this pathway leads to tumorigenesis in both human and mouse. However, their interaction is still a mystery because BMP-Smad pathway is a complex pathway. Previous studies have shown that deficiency of p53 gene leads to activation of BMP-Smad pathway. Hence, in this project, DNA damage proteins (p53 and ATM) were used to test the effect of Smad1 whether there is a possible link between ATM-p53 and BMP-Smad pathway. The experiment findings have shown that elevation of Smad1 plays similar role as p53 in DNA damage response, cell transformation and tumorigenesis. Furthermore, Smad1 appears to up-regulate when p53 and ATM are deficient. Hence, a failure in ATM-p53 pathway activates the BMP-Smad1 pathway which may serve as a compensatory mechanism. This study and the results obtained establish that BMP-Smad1 signaling is an integral part of DNA damage response. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2009-05-28T01:55:40Z 2009-05-28T01:55:40Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/16673 en Nanyang Technological University 96 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Chemical engineering::Biotechnology
spellingShingle DRNTU::Engineering::Chemical engineering::Biotechnology
Gan, Hwee Yee
BMP-smad pathway in DNA damage response
description DNA damage response is a mechanism that can prevents cancer development. In DNA damage response, ATM-p53 pathway is one of the pathways activated to induce DNA repair, cell cycle arrest and apoptosis which ultimately prevent tumorgenesis. Recent genetic studies have revealed that BMP-Smad pathway has a function that suppresses tumorgenesis. An inactivation of this pathway leads to tumorigenesis in both human and mouse. However, their interaction is still a mystery because BMP-Smad pathway is a complex pathway. Previous studies have shown that deficiency of p53 gene leads to activation of BMP-Smad pathway. Hence, in this project, DNA damage proteins (p53 and ATM) were used to test the effect of Smad1 whether there is a possible link between ATM-p53 and BMP-Smad pathway. The experiment findings have shown that elevation of Smad1 plays similar role as p53 in DNA damage response, cell transformation and tumorigenesis. Furthermore, Smad1 appears to up-regulate when p53 and ATM are deficient. Hence, a failure in ATM-p53 pathway activates the BMP-Smad1 pathway which may serve as a compensatory mechanism. This study and the results obtained establish that BMP-Smad1 signaling is an integral part of DNA damage response.
author2 Liao Kin
author_facet Liao Kin
Gan, Hwee Yee
format Final Year Project
author Gan, Hwee Yee
author_sort Gan, Hwee Yee
title BMP-smad pathway in DNA damage response
title_short BMP-smad pathway in DNA damage response
title_full BMP-smad pathway in DNA damage response
title_fullStr BMP-smad pathway in DNA damage response
title_full_unstemmed BMP-smad pathway in DNA damage response
title_sort bmp-smad pathway in dna damage response
publishDate 2009
url http://hdl.handle.net/10356/16673
_version_ 1759854529226997760