X-ray structures of plasmodium falciparum falcilysin in complex with novel antimalarial compounds

• Main Author: T Pravin
• Other Authors: Julien Lescar
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/166915
• Institution: Nanyang Technological University

As Plasmodium falciparum malaria becomes increasingly resistant to gold-standard medical interventions including chloroquine, the situation calls for an innovative counterattack. Falcilysin (FLN), a P. falciparum protein crucial for parasite survival, has become an attractive target for synthesising...