Selective one-pot multicomponent synthesis of N-substituted 2,3,5-functionalized 3-cyanopyrroles via the reaction between α-hydroxyketones, oxoacetonitriles, and primary amines

• Main Authors: Xia, Mengxin, Moussa, Ziad, Judeh, Zaher M. A.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Chemical engineering; Pyrroles; Carbohydrates
• Online Access: https://hdl.handle.net/10356/167022
• Institution: Nanyang Technological University

A one-step, three-component reaction between α-hydroxyketones, oxoacetonitriles, and primary amines gives N-substituted 2,3,5-functionalized 3-cyanopyrroles with complete selectivity in up to 90% isolated yields. The reaction worked on a wide substrate scope under mild reaction conditions (AcOH as a...