A practical synthesis of densely functionalized pyrroles via a three-component cascade reaction between carbohydrates, oxoacetonitriles, and ammonium acetate

• المؤلفون الرئيسيون: Xia, Mengxin, Lambu, Mallikharjuna Rao, Tatina, Madhu Babu, Judeh, Zaher M. A.
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Engineering::Chemical engineering; Carbohydrates; Mass Spectrometry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/159560
• المؤسسة: Nanyang Technological University

A practical three-component reaction between unactivated carbohydrates, oxoacetonitriles, and ammonium acetate gave densely functionalized pyrroles in 75-96% yields. Disaccharides afforded novel pyrrolo-glycosides. This metal-free, Et3N-catalyzed cascade reaction proceeded with exclusive chemo-, reg...