Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation

Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation

Conventionally, transcranial direct current stimulation (tDCS) aims to focalize the current reaching the target region-of-interest (ROI). The focality can be quantified by the dose-target-determination-index (DTDI). Despite having a uniform tDCS setup, some individuals receive focal stimulation (hig...

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Bibliographic Details
Main Authors: Kashyap, Rajan, Bhattacharjee, Sagarika, Bharath, Rose Dawn, Venkatasubramanian, Ganesan, Udupa, Kaviraja, Bashir, Shahid, Oishi, Kenichi, Desmond, John E., Chen, Annabel Shen -Hsing, Guan, Cuntai
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Science::Medicine
Transcranial Direct Current Stimulation
Systematic-Approach-for-TDCS-Analysis
Online Access:https://hdl.handle.net/10356/168569
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Institution: Nanyang Technological University
Language: English
Description
Summary:Conventionally, transcranial direct current stimulation (tDCS) aims to focalize the current reaching the target region-of-interest (ROI). The focality can be quantified by the dose-target-determination-index (DTDI). Despite having a uniform tDCS setup, some individuals receive focal stimulation (high DTDI) while others show reduced focality ("non-focal"). The volume of cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) underlying each ROI govern the tDCS current distribution inside the brain, thereby regulating focality.

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