Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation
Conventionally, transcranial direct current stimulation (tDCS) aims to focalize the current reaching the target region-of-interest (ROI). The focality can be quantified by the dose-target-determination-index (DTDI). Despite having a uniform tDCS setup, some individuals receive focal stimulation (hig...
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sg-ntu-dr.10356-1685692023-06-09T15:36:54Z Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation Kashyap, Rajan Bhattacharjee, Sagarika Bharath, Rose Dawn Venkatasubramanian, Ganesan Udupa, Kaviraja Bashir, Shahid Oishi, Kenichi Desmond, John E. Chen, Annabel Shen -Hsing Guan, Cuntai Lee Kong Chian School of Medicine (LKCMedicine) School of Computer Science and Engineering School of Social Sciences Centre for Research and Development in Learning (CRADLE) Science::Medicine Transcranial Direct Current Stimulation Systematic-Approach-for-TDCS-Analysis Conventionally, transcranial direct current stimulation (tDCS) aims to focalize the current reaching the target region-of-interest (ROI). The focality can be quantified by the dose-target-determination-index (DTDI). Despite having a uniform tDCS setup, some individuals receive focal stimulation (high DTDI) while others show reduced focality ("non-focal"). The volume of cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) underlying each ROI govern the tDCS current distribution inside the brain, thereby regulating focality. Agency for Science, Technology and Research (A*STAR) Published version This work was partially supported by the RIE2020 AME Programmatic Fund, Singapore (grant no. A20G8b0102). JD received additional support from NIH/NICHD (grant no. P50 HD103538). RK and SaB received support from the Department of Biotechnology (DBT) Ramalingaswami Re-entry fellowship (2021), under the Government of India (grant no. BT/HRD/35/02/2006). GV acknowledged the support of DBT— Wellcome Trust India Alliance (grant no. IA/CRC/19/1/610005) and DBT, the Government of India [grant no. BT/HRD-NBANWB/38/2019-20 (6)]. 2023-06-06T01:38:29Z 2023-06-06T01:38:29Z 2022 Journal Article Kashyap, R., Bhattacharjee, S., Bharath, R. D., Venkatasubramanian, G., Udupa, K., Bashir, S., Oishi, K., Desmond, J. E., Chen, A. S. -. & Guan, C. (2022). Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation. Frontiers in Human Neuroscience, 16, 952602-. https://dx.doi.org/10.3389/fnhum.2022.952602 1662-5161 https://hdl.handle.net/10356/168569 10.3389/fnhum.2022.952602 36118967 2-s2.0-85138181957 16 952602 en A20G8b0102 Frontiers in Human Neuroscience © 2022 Kashyap, Bhattacharjee, Bharath, Venkatasubramanian, Udupa, Bashir, Oishi, Desmond, Chen and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
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Science::Medicine Transcranial Direct Current Stimulation Systematic-Approach-for-TDCS-Analysis |
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Science::Medicine Transcranial Direct Current Stimulation Systematic-Approach-for-TDCS-Analysis Kashyap, Rajan Bhattacharjee, Sagarika Bharath, Rose Dawn Venkatasubramanian, Ganesan Udupa, Kaviraja Bashir, Shahid Oishi, Kenichi Desmond, John E. Chen, Annabel Shen -Hsing Guan, Cuntai Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| description |
Conventionally, transcranial direct current stimulation (tDCS) aims to focalize the current reaching the target region-of-interest (ROI). The focality can be quantified by the dose-target-determination-index (DTDI). Despite having a uniform tDCS setup, some individuals receive focal stimulation (high DTDI) while others show reduced focality ("non-focal"). The volume of cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) underlying each ROI govern the tDCS current distribution inside the brain, thereby regulating focality. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Kashyap, Rajan Bhattacharjee, Sagarika Bharath, Rose Dawn Venkatasubramanian, Ganesan Udupa, Kaviraja Bashir, Shahid Oishi, Kenichi Desmond, John E. Chen, Annabel Shen -Hsing Guan, Cuntai |
| format |
Article |
| author |
Kashyap, Rajan Bhattacharjee, Sagarika Bharath, Rose Dawn Venkatasubramanian, Ganesan Udupa, Kaviraja Bashir, Shahid Oishi, Kenichi Desmond, John E. Chen, Annabel Shen -Hsing Guan, Cuntai |
| author_sort |
Kashyap, Rajan |
| title |
Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| title_short |
Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| title_full |
Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| title_fullStr |
Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| title_full_unstemmed |
Variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| title_sort |
variation of cerebrospinal fluid in specific regions regulates focality in transcranial direct current stimulation |
| publishDate |
2023 |
| url |
https://hdl.handle.net/10356/168569 |
| _version_ |
1772827423485722624 |