Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras

Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras

Epigenetic mediation through bromodomain and extraterminal (BET) proteins have progressively translated protein imbalance into effective cancer treatment. Perturbation of druggable BET proteins through proteolysis-targeting chimeras (PROTACs) has recently contributed to the discovery of effective th...

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Bibliographic Details
Main Authors: Do, Thang Cong, Lau, Junwei, Sun, Caixia, Liu, Songhan, Kha, Khoa Tuan, Lim, Seok Ting, Oon, Yu Yang, Kwan, Yuet Ping, Ma, Jiajia, Mu, Yuguang, Liu, Xiaogang, Carney, Thomas James, Wang, Xiaomeng, Xing, Bengang
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2023
Subjects:
Science::Chemistry
Chemical Activation
Enzymes
Online Access:https://hdl.handle.net/10356/168695
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/168695

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