Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras

• Main Authors: Do, Thang Cong, Lau, Junwei, Sun, Caixia, Liu, Songhan, Kha, Khoa Tuan, Lim, Seok Ting, Oon, Yu Yang, Kwan, Yuet Ping, Ma, Jiajia, Mu, Yuguang, Liu, Xiaogang, Carney, Thomas James, Wang, Xiaomeng, Xing, Bengang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Chemical Activation; Enzymes
• Online Access: https://hdl.handle.net/10356/168695
• Institution: Nanyang Technological University

Epigenetic mediation through bromodomain and extraterminal (BET) proteins have progressively translated protein imbalance into effective cancer treatment. Perturbation of druggable BET proteins through proteolysis-targeting chimeras (PROTACs) has recently contributed to the discovery of effective th...