Molecular architecture of the Chikungunya virus replication complex

• Main Authors: Tan, Yaw Bia, Chmielewski, David, Law, Michelle Cheok Yien, Zhang, Kuo, He, Yu, Chen, Muyuan, Jin, Jing, Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Cellular Contexts; Chikungunya
• Online Access: https://hdl.handle.net/10356/168697
• Institution: Nanyang Technological University

To better understand how positive-strand (+) RNA viruses assemble membrane-associated replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected cells, we determined both the high-resolution structure of the core RNA replicase of chikungunya virus and the native RC...