Accurate identification of DNA replication origin by fusing epigenomics and chromatin interaction information

• Main Authors: Dao, Fu-Ying, Lv, Hao, Fullwood, Melissa Jane, Lin, Hao
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; DNA; Cell Lines
• Online Access: https://hdl.handle.net/10356/168771
• Institution: Nanyang Technological University

DNA replication initiation is a complex process involving various genetic and epigenomic signatures. The correct identification of replication origins (ORIs) could provide important clues for the study of a variety of diseases caused by replication. Here, we design a computational approach named iOR...