Population-specific positive selection on low CR1 expression in malaria-endemic regions

• Main Authors: Lorenzini, Paolo Alberto, Gusareva, Elena S., Ghosh, Amit Gourav, Nurul Adilah Binte Ramli, Preiser, Peter Rainer, Kim, Hie Lim
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Complement Receptor; Malaria
• Online Access: https://hdl.handle.net/10356/168813
• Institution: Nanyang Technological University

Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the brain bloodstream, causing cerebral malaria, the most severe for...