Population-specific positive selection on low CR1 expression in malaria-endemic regions

• المؤلفون الرئيسيون: Lorenzini, Paolo Alberto, Gusareva, Elena S., Ghosh, Amit Gourav, Nurul Adilah Binte Ramli, Preiser, Peter Rainer, Kim, Hie Lim
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Biological sciences; Complement Receptor; Malaria
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/168813
• المؤسسة: Nanyang Technological University

Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the brain bloodstream, causing cerebral malaria, the most severe for...