Electrical stimulation therapy and HA/TCP composite scaffolds modulate the Wnt pathways in bone regeneration of critical-sized defects

• Main Authors: Helaehil, Júlia Venturini, Helaehil, Luiza Venturini, Alves, Laryssa Fernanda, Huang, Boyang, Santamaria-Jr, Milton, Bartolo, Paulo, Caetano, Guilherme Ferreira
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Mechanical engineering; Bioprinting; Microcurrent
• Online Access: https://hdl.handle.net/10356/168886
• Institution: Nanyang Technological University

Critical bone defects are the most difficult challenges in the area of tissue repair. Polycaprolactone (PCL) scaffolds, associated with hydroxyapatite (HA) and tricalcium phosphate (TCP), are reported to have an enhanced bioactivity. Moreover, the use of electrical stimulation (ES) has overcome the...