Organobase-catalyzed umpolung of amides: the generation and transfer of carbamoyl anion

Organobase-catalyzed umpolung of amides: the generation and transfer of carbamoyl anion

A novel organobase-catalyzed umpolung reaction of amides was disclosed. This method provides an efficient method to generate and transfer carbamoyl anions. In this transformation, some of the inherent disadvantages of carbamoyl metal were avoided. The mechanistic analysis revealed that the reaction...

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Bibliographic Details
Main Authors: Li, Qi, Zhang, Wang, Zhu, Chen, Pan, Hong, Shi, Kang-Yue, Zhang, Yicheng, Han, Man-Yi, Tan, Choon-Hong
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
Subjects:
Science::Chemistry
Catalysis
Negative Ions
Online Access:https://hdl.handle.net/10356/168937
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Institution: Nanyang Technological University
Language: English
Description
Summary:A novel organobase-catalyzed umpolung reaction of amides was disclosed. This method provides an efficient method to generate and transfer carbamoyl anions. In this transformation, some of the inherent disadvantages of carbamoyl metal were avoided. The mechanistic analysis revealed that the reaction proceeds through polarity inversion of amide, and various carbamoyl anions were applied in the reaction. Moreover, a wide range of substrates was achieved with moderate to excellent yield.

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