Organobase-catalyzed umpolung of amides: the generation and transfer of carbamoyl anion

• Main Authors: Li, Qi, Zhang, Wang, Zhu, Chen, Pan, Hong, Shi, Kang-Yue, Zhang, Yicheng, Han, Man-Yi, Tan, Choon-Hong
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Catalysis; Negative Ions
• Online Access: https://hdl.handle.net/10356/168937
• Institution: Nanyang Technological University

A novel organobase-catalyzed umpolung reaction of amides was disclosed. This method provides an efficient method to generate and transfer carbamoyl anions. In this transformation, some of the inherent disadvantages of carbamoyl metal were avoided. The mechanistic analysis revealed that the reaction...