Carbene-catalyzed α,γ-deuteration of enals under oxidative conditions

• Main Authors: Zhang, Xiaolei, Chen, Qiao, Song, Runjiang, Xu, Jun, Tian, Weiyi, Li, Shaoyuan, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Carbene Catalysis; Allyl Group
• Online Access: https://hdl.handle.net/10356/148639
• Institution: Nanyang Technological University

Organic compounds with deuterated allyl groups are very attractive for drug entities to enhance pharmacokinetic properties, since allylic C-H bonds are prone to metabolic oxidation and the deuterated versions can be less prone to such metabolism. However, direct deuteration at allylic C-H moieties i...