Carbene-catalyzed α,γ-deuteration of enals under oxidative conditions

• المؤلفون الرئيسيون: Zhang, Xiaolei, Chen, Qiao, Song, Runjiang, Xu, Jun, Tian, Weiyi, Li, Shaoyuan, Jin, Zhichao, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Chemistry; Carbene Catalysis; Allyl Group
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/148639

Organic compounds with deuterated allyl groups are very attractive for drug entities to enhance pharmacokinetic properties, since allylic C-H bonds are prone to metabolic oxidation and the deuterated versions can be less prone to such metabolism. However, direct deuteration at allylic C-H moieties i...