Carbene-catalyzed α,γ-deuteration of enals under oxidative conditions

• Main Authors: Zhang, Xiaolei, Chen, Qiao, Song, Runjiang, Xu, Jun, Tian, Weiyi, Li, Shaoyuan, Jin, Zhichao, Chi, Robin Yonggui
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Chemistry; Carbene Catalysis; Allyl Group
• 在線閱讀: https://hdl.handle.net/10356/148639
• 機構: Nanyang Technological University

Organic compounds with deuterated allyl groups are very attractive for drug entities to enhance pharmacokinetic properties, since allylic C-H bonds are prone to metabolic oxidation and the deuterated versions can be less prone to such metabolism. However, direct deuteration at allylic C-H moieties i...