Prediction of NHC-catalyzed chemoselective functionalizations of carbonyl compounds : a general mechanistic map

• Main Authors: Li, Xue, Xu, Jun, Li, Shi-Jun, Qu, Ling-Bo, Li, Zhongjun, Chi, Robin Yonggui, Wei, Donghui, Lan, Yu
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Catalysis; Forecasting
• Online Access: https://hdl.handle.net/10356/155112
• Institution: Nanyang Technological University

Generally, N-heterocyclic carbene (NHC) complexed with carbonyl compounds would transform into several important active intermediates, i.e., enolates, Breslow intermediates, or acylazolium intermediates, which act as either a nucleophile (Nu) or an electrophile (E) to react with the other E/Nu partn...