NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release

• Main Authors: Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Asymmetric Catalysis; Cross Coupling Reaction
• Online Access: https://hdl.handle.net/10356/170931
• Institution: Nanyang Technological University

A carbene-catalyzed asymmetric access to chiral β-cyano carboxylic esters is disclosed. The reaction proceeds between β,β-disubstituted enals and aromatic thiols involving enantioselective protonation of enal β-carbon. Two main factors contribute to the success of this reaction. One involves in situ...