NHC-catalyzed enantioselective access to β-cyano carboxylic esters via in situ substrate alternation and release
A carbene-catalyzed asymmetric access to chiral β-cyano carboxylic esters is disclosed. The reaction proceeds between β,β-disubstituted enals and aromatic thiols involving enantioselective protonation of enal β-carbon. Two main factors contribute to the success of this reaction. One involves in situ...
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Main Authors: | Wang, Qingyun, Wu, Shuquan, Zou, Juan, Liang, Xuyang, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui |
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Other Authors: | School of Chemistry, Chemical Engineering and Biotechnology |
Format: | Article |
Language: | English |
Published: |
2023
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/170931 |
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Institution: | Nanyang Technological University |
Language: | English |
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