Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization

DNA sequence composition determines the topology and stability of G-quadruplexes (G4s). Bulged G-quadruplex structures (G4-Bs) are a subset of G4s characterized by 3D conformations with bulges. Current search algorithms fail to capture stable G4-B, making their genome-wide study infeasible. Here, we...

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Main Authors: Papp, Csaba, Mukundan, Vineeth Thachappilly, Jenjaroenpun, Piroon, Winnerdy, Fernaldo Richtia, Ow, Ghim Siong, Phan, Anh Tuân, Kuznetsov, Vladimir A.
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2023
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Online Access:https://hdl.handle.net/10356/169159
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Institution: Nanyang Technological University
Language: English