Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization

• Main Authors: Papp, Csaba, Mukundan, Vineeth Thachappilly, Jenjaroenpun, Piroon, Winnerdy, Fernaldo Richtia, Ow, Ghim Siong, Phan, Anh Tuân, Kuznetsov, Vladimir A.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Human Genome; Nucleotide Sequence
• Online Access: https://hdl.handle.net/10356/169159
• Institution: Nanyang Technological University

DNA sequence composition determines the topology and stability of G-quadruplexes (G4s). Bulged G-quadruplex structures (G4-Bs) are a subset of G4s characterized by 3D conformations with bulges. Current search algorithms fail to capture stable G4-B, making their genome-wide study infeasible. Here, we...