Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

• المؤلفون الرئيسيون: Zeng, Jialiu, Acin-Perez, Rebeca, Assali, Essam A., Martin, Andrew, Brownstein, Alexandra J., Petcherski, Anton, Fernández-del-Rio, Lucía, Xiao, Ruiqing, Lo, Chih Hung, Shum, Michaël, Liesa, Marc, Han, Xue, Shirihai, Orian S., Grinstaff, Mark W.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Nonalcoholic Fatty Liver; Lysosome
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/169191

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce autophagic flux. We investigate whether restoration of lysosomal function in NAFLD recovers autophagic flux, mitocho...