Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

• Main Authors: Zeng, Jialiu, Acin-Perez, Rebeca, Assali, Essam A., Martin, Andrew, Brownstein, Alexandra J., Petcherski, Anton, Fernández-del-Rio, Lucía, Xiao, Ruiqing, Lo, Chih Hung, Shum, Michaël, Liesa, Marc, Han, Xue, Shirihai, Orian S., Grinstaff, Mark W.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Nonalcoholic Fatty Liver; Lysosome
• Online Access: https://hdl.handle.net/10356/169191
• Institution: Nanyang Technological University

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce autophagic flux. We investigate whether restoration of lysosomal function in NAFLD recovers autophagic flux, mitocho...