Membrane potential-dependent uptake of cationic oligoimidazolium mediates bacterial DNA damage and death

• Main Authors: Yong, Melvin, Kok, Zhi Y., Koh, Chong Hui, Zhong, Wenbin, Ng, Justin T. Y., Mu, Yuguang, Chan-Park, Mary B., Gan, Yunn-Hwen
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Engineering::Bioengineering; DNA Damage; Cationic
• Online Access: https://hdl.handle.net/10356/169440
• Institution: Nanyang Technological University

The treatment of bacterial infections is becoming increasingly challenging with the emergence of antimicrobial resistance. Thus, the development of antimicrobials with novel mechanisms of action is much needed. Previously, we designed several cationic main-chain imidazolium compounds and identified...