A concise synthesis of pyrrole-based drug candidates from α-hydroxyketones, 3-oxobutanenitrile, and anilines

• Main Authors: Xia, Mengxin, Santoso, Mardi, Moussa, Ziad, Judeh, Zaher M. A.
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Chemical engineering; Pyrroles; Three-Component Reactions
• Online Access: https://hdl.handle.net/10356/169534
• Institution: Nanyang Technological University

A simple and concise three-component synthesis of a key pyrrole framework was developed from the reaction between α-hydroxyketones, oxoacetonitriles, and anilines. The synthesis was used to obtain several pyrrole-based drug candidates, including COX-2 selective NSAID, antituberculosis lead candidate...