Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2

• Main Authors: Nocka, Laura M., Eisen, Timothy J., Iavarone, Anthony T., Groves, Jay T., Kuriyan, John
• Other Authors: Institute for Digital Molecular Analytics and Science (IDMxS)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Protein-Tyrosine Kinases; Dimerization
• Online Access: https://hdl.handle.net/10356/169560
• Institution: Nanyang Technological University

The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec homology (PH-TH) module connected by a proline-rich linker to a 'Src module', an SH3-SH2-kinase unit also found in Src-family kinases and Abl. We showed previously that Btk is activated by PH-TH dimerization, wh...