Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
The Tec-family kinase Btk contains a lipid-binding Pleckstrin homology and Tec homology (PH-TH) module connected by a proline-rich linker to a 'Src module', an SH3-SH2-kinase unit also found in Src-family kinases and Abl. We showed previously that Btk is activated by PH-TH dimerization, wh...
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Main Authors: | Nocka, Laura M., Eisen, Timothy J., Iavarone, Anthony T., Groves, Jay T., Kuriyan, John |
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Other Authors: | Institute for Digital Molecular Analytics and Science (IDMxS) |
Format: | Article |
Language: | English |
Published: |
2023
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/169560 |
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Institution: | Nanyang Technological University |
Language: | English |
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