Conditioning on parental mating types can reduce necessary assumptions for Mendelian randomization

• Main Authors: Ejima, Keisuke, Liu, Nianjun, Mestre, Luis Miguel, de Los Campos, Gustavo, Allison, David B.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Mendelian Randomization; Genetic Epidemiology
• Online Access: https://hdl.handle.net/10356/169677
• Institution: Nanyang Technological University

Mendelian randomization (MR) has become a common tool used in epidemiological studies. However, when confounding variables are correlated with the instrumental variable (in this case, a genetic/variant/marker), the estimation can remain biased even with MR. We propose conditioning on parental mating...