The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

• Main Authors: Wu, Kan Xing, Yogarajah, Thinesshwary, Loe, Marcus Wing Choy, Kaur, Parveen, Lee, Regina Ching Hua, Mok, Chee Keng, Wong, Yi Hao, Phuektes, Patchara, Yeo, Li Sze, Chow, Vincent T. K., Tan, Yong Wah, Chu, Justin Jang Hann
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Positive-Sense RNA Viruses; Peruvoside
• Online Access: https://hdl.handle.net/10356/169688
• Institution: Nanyang Technological University

Positive-sense RNA viruses modify intracellular calcium stores, endoplasmic reticulum and Golgi apparatus (Golgi) to generate membranous replication organelles known as viral factories. Viral factories provide a conducive and substantial enclave for essential virus replication via concentrating nece...