Conservation of red blood cell signalling in Plasmodium merozoite invasion

• Main Author: Yong, James Jia Ming
• Other Authors: Peter Preiser
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences::Molecular biology; Science::Biological sciences::Microbiology::Microorganisms
• Online Access: https://hdl.handle.net/10356/169702
• Institution: Nanyang Technological University

Red blood cells (RBC) possess essential signalling cascades that are involved in Plasmodium merozoite invasion. While P. falciparum reticulocyte binding protein homologue 5 (RH5) binding to RBC surface receptor Basigin is crucial for invasion and induces calcium (Ca2+) influx in the RBC, the mechani...