Understanding artemisinin compounds mode of action in killing Plasmodium falciparum by using mass spectrometry cellular thermal shift assay

Plasmodium falciparum (Pf) is a lethal cause of malaria, which is a global health burden with an estimated 627 thousand deaths during 2020. Dihydroartemisinin (DHA)-piperaquine is one form of artemisinin-combination therapies (ACTs) used as a first-line antimalarial drug. Previous studies show...

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Bibliographic Details
Main Author: Go, Ka Diam
Other Authors: Zbynek Bozdech
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2023
Subjects:
Online Access:https://hdl.handle.net/10356/170075
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Institution: Nanyang Technological University
Language: English