Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

• Main Authors: Dembele, L, Gupta, D.K, Lim, M.Y.-X, Ang, X, Selva, J.J, Chotivanich, K, Nguon, C, Dondorp, A.M, Bonamy, G.M.C, Diagana, T.T, Bifania, P
• 其他作者: MICROBIOLOGY AND IMMUNOLOGY
• 格式: Article
• 出版: American Society for Microbiology 2020
• 主題: antimalarial agent; dihydroartemisinin; dimethyl sulfoxide; gnf 179; imidazole derivative; kdu 691; kelch 13 protein; membrane protein; microorganism protein; piperazine derivative; unclassified drug; artemisinin derivative; protozoal protein; antimalarial activity; antimalarial drug resistance; antimalarial drug susceptibility; apoptosis; Article; cell viability; combination drug therapy; controlled study; development; dormancy; drug efficacy; drug mechanism; drug potentiation; erythrocyte; genotype; IC50; in vitro study; nonhuman; Plasmodium falciparum; priority journal; recrudescence; schizont; trophozoite; wild type; drug effect; drug sensitivity; genetics; metabolism; Antimalarials; Artemisinins; Imidazoles; Parasitic Sensitivity Tests; Piperazines; Protozoan Proteins; Schizonts; Trophozoites
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/175115
• 機構: National University of Singapore

10.1128/AAC.02235-17