Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

10.1128/AAC.02235-17

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Main Authors:	Dembele, L, Gupta, D.K, Lim, M.Y.-X, Ang, X, Selva, J.J, Chotivanich, K, Nguon, C, Dondorp, A.M, Bonamy, G.M.C, Diagana, T.T, Bifania, P
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	antimalarial agent dihydroartemisinin dimethyl sulfoxide gnf 179 imidazole derivative kdu 691 kelch 13 protein membrane protein microorganism protein piperazine derivative unclassified drug artemisinin derivative protozoal protein antimalarial activity antimalarial drug resistance antimalarial drug susceptibility apoptosis Article cell viability combination drug therapy controlled study development dormancy drug efficacy drug mechanism drug potentiation erythrocyte genotype IC50 in vitro study nonhuman Plasmodium falciparum priority journal recrudescence schizont trophozoite wild type drug effect drug sensitivity genetics metabolism Antimalarials Artemisinins Imidazoles Parasitic Sensitivity Tests Piperazines Protozoan Proteins Schizonts Trophozoites
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175115
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1751152024-03-27T08:17:19Z Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro Dembele, L Gupta, D.K Lim, M.Y.-X Ang, X Selva, J.J Chotivanich, K Nguon, C Dondorp, A.M Bonamy, G.M.C Diagana, T.T Bifania, P MICROBIOLOGY AND IMMUNOLOGY antimalarial agent dihydroartemisinin dimethyl sulfoxide gnf 179 imidazole derivative kdu 691 kelch 13 protein membrane protein microorganism protein piperazine derivative unclassified drug antimalarial agent artemisinin derivative imidazole derivative piperazine derivative protozoal protein antimalarial activity antimalarial drug resistance antimalarial drug susceptibility apoptosis Article cell viability combination drug therapy controlled study development dormancy drug efficacy drug mechanism drug potentiation erythrocyte genotype IC50 in vitro study nonhuman Plasmodium falciparum priority journal recrudescence schizont trophozoite wild type drug effect drug sensitivity genetics metabolism Plasmodium falciparum Antimalarials Artemisinins Imidazoles Parasitic Sensitivity Tests Piperazines Plasmodium falciparum Protozoan Proteins Schizonts Trophozoites 10.1128/AAC.02235-17 Antimicrobial Agents and Chemotherapy 62 5 e02235-17 2020-09-09T04:08:57Z 2020-09-09T04:08:57Z 2018 Article Dembele, L, Gupta, D.K, Lim, M.Y.-X, Ang, X, Selva, J.J, Chotivanich, K, Nguon, C, Dondorp, A.M, Bonamy, G.M.C, Diagana, T.T, Bifania, P (2018). Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro. Antimicrobial Agents and Chemotherapy 62 (5) : e02235-17. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02235-17 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/175115 American Society for Microbiology Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antimalarial agent dihydroartemisinin dimethyl sulfoxide gnf 179 imidazole derivative kdu 691 kelch 13 protein membrane protein microorganism protein piperazine derivative unclassified drug antimalarial agent artemisinin derivative imidazole derivative piperazine derivative protozoal protein antimalarial activity antimalarial drug resistance antimalarial drug susceptibility apoptosis Article cell viability combination drug therapy controlled study development dormancy drug efficacy drug mechanism drug potentiation erythrocyte genotype IC50 in vitro study nonhuman Plasmodium falciparum priority journal recrudescence schizont trophozoite wild type drug effect drug sensitivity genetics metabolism Plasmodium falciparum Antimalarials Artemisinins Imidazoles Parasitic Sensitivity Tests Piperazines Plasmodium falciparum Protozoan Proteins Schizonts Trophozoites
spellingShingle	antimalarial agent dihydroartemisinin dimethyl sulfoxide gnf 179 imidazole derivative kdu 691 kelch 13 protein membrane protein microorganism protein piperazine derivative unclassified drug antimalarial agent artemisinin derivative imidazole derivative piperazine derivative protozoal protein antimalarial activity antimalarial drug resistance antimalarial drug susceptibility apoptosis Article cell viability combination drug therapy controlled study development dormancy drug efficacy drug mechanism drug potentiation erythrocyte genotype IC50 in vitro study nonhuman Plasmodium falciparum priority journal recrudescence schizont trophozoite wild type drug effect drug sensitivity genetics metabolism Plasmodium falciparum Antimalarials Artemisinins Imidazoles Parasitic Sensitivity Tests Piperazines Plasmodium falciparum Protozoan Proteins Schizonts Trophozoites Dembele, L Gupta, D.K Lim, M.Y.-X Ang, X Selva, J.J Chotivanich, K Nguon, C Dondorp, A.M Bonamy, G.M.C Diagana, T.T Bifania, P Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro
description	10.1128/AAC.02235-17
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Dembele, L Gupta, D.K Lim, M.Y.-X Ang, X Selva, J.J Chotivanich, K Nguon, C Dondorp, A.M Bonamy, G.M.C Diagana, T.T Bifania, P
format	Article
author	Dembele, L Gupta, D.K Lim, M.Y.-X Ang, X Selva, J.J Chotivanich, K Nguon, C Dondorp, A.M Bonamy, G.M.C Diagana, T.T Bifania, P
author_sort	Dembele, L
title	Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro
title_short	Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro
title_full	Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro
title_fullStr	Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro
title_full_unstemmed	Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro
title_sort	imidazolopiperazines kill both rings and dormant rings in wild-type and k13 artemisinin-resistant plasmodium falciparum in vitro
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175115
_version_	1795301107485900800

Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

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