A novel eukaryotic RdRP-dependent small RNA pathway represses antiviral immunity by controlling an ERK pathway component in the black-legged tick

• Main Authors: Feng, Canran, Torimaru, Kyosuke, Lim, Mandy Yu Theng, Chak, Li-Ling, Shiimori, Masami, Tsuji, Kosuke, Tanaka, Tetsuya, Iida, Junko, Okamura, Katsutomo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Small Interfering RNA; Eukaryote
• Online Access: https://hdl.handle.net/10356/169716
• Institution: Nanyang Technological University

Small regulatory RNAs (sRNAs) are involved in antiviral defense and gene regulation. Although roles of RNA-dependent RNA Polymerases (RdRPs) in sRNA biology are extensively studied in nematodes, plants and fungi, understanding of RdRP homologs in other animals is still lacking. Here, we study sRNAs...