HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

• Main Authors: Chan, Jun Wei, Neo, Claire Wen Ying, Ghosh, Soumita, Choi, Hyungwon, Lim, Su Chi, Tai, E Shyong, Teo, Adrian Kee Keong
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Chromatin Immunoprecipitation; Ubiquitin Protein Ligase
• Online Access: https://hdl.handle.net/10356/169775
• Institution: Nanyang Technological University

Renal defects in maturity onset diabetes of the young 3 (MODY3) patients and Hnf1a-/- mice suggest an involvement of HNF1A in kidney development and/or its function. Although numerous studies have leveraged on Hnf1α-/- mice to infer some transcriptional targets and function of HNF1A in mouse kidneys...