Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis

• Main Authors: da Silva, Ronni A. G., Wong, Jun Jie, Antypas, Haris, Choo, Pei Yi, Goh, Karlyn, Jolly, Shreya, Liang, Cui, Tay, Leona Kwan Sing, Veleba, Mark, Hu, Guangan, Chen, Jianzhu, Kline, Kimberly A.
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Biological sciences; Antibiotics Resistance
• 在線閱讀: https://hdl.handle.net/10356/169848

Antibiotic resistance critically limits treatment options for infection caused by opportunistic pathogens such as enterococci. Here, we investigate the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vitro and in vivo against vancomycin-resistant Enterococcus faec...