Maintaining supersaturation generation and protein integrity of amorphous curcumin-albumin nanoplex during storage by freeze drying with trehalose

• Main Authors: Tran, The-Thien, Chua, Angeline, Pu, Siyu, Park, Jin-Won, Hadinoto, Kunn
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Curcumin Nanoparticles; Bovine Serum Albumin
• Online Access: https://hdl.handle.net/10356/170309
• Institution: Nanyang Technological University

Amorphous curcumin-albumin nanoplex (size ≈ 100 nm, 55 wt% curcumin content) is a highly promising nanoscale delivery system of curcumin attributed to its high curcumin's payload and kinetic solubility. Its storage stability, however, has not been established. Previously, freeze-dried nanoplex...