Carbene-catalyzed access to thiochromene derivatives: control of reaction pathways via slow release of thiols from disulfides

• Main Authors: Wu, Qifei, Wu, Shuquan, Zou, Juan, Wang, Qingyun, Mou, Chengli, Zheng, Pengcheng, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Chemistry; Heterocyclic Compounds; Carbenes
• Online Access: https://hdl.handle.net/10356/170320
• Institution: Nanyang Technological University

Substrates containing disulfide bonds, which are more stable and less smelling, could be used as thiophenol precursors in organic synthesis. Herein, an N-heterocyclic carbene (NHC)-catalyzed reaction between α-bromoenals and 2,2'-dithiodibenzaldehydes was developed. Through the sustained releas...