Cu single atom nanozyme based high-efficiency mild photothermal therapy through cellular metabolic regulation

Cu single atom nanozyme based high-efficiency mild photothermal therapy through cellular metabolic regulation

Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced mild PTT. On one hand, LIK066 inhibits glucose...

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Bibliographic Details
Main Authors: Chang, Mengyu, Hou, Zhiyao, Wang, Man, Wen, Ding, Li, Chunxia, Liu, Yuhui, Zhao, Yanli, Lin, Jun
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2023
Subjects:
Science::Chemistry
Heat Shock Proteins
Sodium-Dependent Glucose Transporter
Online Access:https://hdl.handle.net/10356/170354
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Institution: Nanyang Technological University
Language: English
Description
Summary:Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced mild PTT. On one hand, LIK066 inhibits glucose uptake by shutting sodium-dependent glucose transporter (SGLT) "valve", effectively blocking the energy source for adenosine triphosphate (ATP) generation. Without sufficient energy, cancer cells cannot synthesize HSPs. On the other hand, Cu SAzyme presents extraordinary multienzyme activities to induce reactive oxygen species (ROS) storm formation, which can damage the existing HSPs in cancer cells. Through a two-pronged strategy of SGLT inhibitor and ROS storm, LIK066-loaded Cu SAzyme shows high efficiency for comprehensive removal of HSPs to realize mild PTT.

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